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Identification of signature metabolites for NAFLD from gut into blood circulation We further selected the differential inflammation-related metabolites in the correlation analysis as independent variables, and established a machine learning model to distinguish different states of NAFLD

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In summary, ferroptosis constructs an immunosuppressive network in PMN-MDSCs through the GSH depletion-GPX4 inactivation-oxidative lipid accumulation axis, providing a theoretical basis for the development of “ferroptosis-immunometabolism” dual-targeted therapy