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An enrichment analysis conducted on UPLC/MS data identified three metabolic pathways that differentiated PD patients from HC: glutathione metabolism, porphyrin metabolism, and tryptophan metabolism (Supplementary Fig

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However, notably, trazodone/nefazodone, pregabalin, gabapentin, Abilify ≤2 mg (low-dose), and midodrine also had more than 50% of positive responses