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Research demonstrates bidirectional gut-brain communication: peripheral BPC-157 administration increased brain serotonin synthesis, produced antidepressant effects, and prevented brain lesions in intestinal resection models

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Gabapentinoids, including gabapentin and pregabalin, bind to the α2δ subunit of presynaptic voltage-gated calcium channels, reducing calcium influx and subsequent release of excitatory neurotransmitters, such as glutamate, noradrenaline, and substance P [67,68,69,70]