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This structural shift enhances the LB2-LB2-mediated dimerization interface for CaSR and GABA B [85, 86] or shortens the LB2-LB2 distance for mGluRs [87], inducing rotation and convergence of the two subunits, further leading to the formation of the TM6-TM6 interface (Fig

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The reaction mixture was concentrated and the crude product was purified by flash chromatography (silica gel, MeOH:DCM 0:1 to 1:9) to afford aniline XT70 (1.45 g, 88%) as a yellow foam