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Patients who do respond meaningfully to the combination may continue cycling AOD-9604 in defined patterns (typically with the 4 to 8 week break between cycles) for as long as the response remains clinically useful

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DOI: 10.14740/jem211w Kwon DR & Park GY (2015) — Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model — Ann Clin Lab Sci 45(4):426–432