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have demonstrated how curcumin could inhibit the total activity of HDACs in prostate cancer cells (LNCaP)

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Several residues like Tyr7 (62.02%), Trp8 (1.25%), Asn54 (0.95%), Ser68 (0.90%), Ser107 (7.30%), and Arg108 (0.80%) seem to play key role in hydrogen bond formation from chain-A