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From the humoral theory of Hippocrates in Greece to Zhongjing Zhang’s Treatise on Cold Damage Diseases (Shanghan Lun) in China, people in different areas have established systems and put forward different theories to guide the advancement of healthcare

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Also, in contrast to glutamate, aspartate cannot sustain its own uptake in cultured astrocytes by oxidative metabolism (Peng et al., 2001), as it should have been able to do in order for the subsequent oxaloacetate-to-malate reduction suggested by LaNoue et al