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These metabolic alterations may also intersect with systemic insulin resistance and oxidative burden, reinforcing the hypothesis that renal dysfunction acts as a metabolic amplifier in PD progression
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Choi and colleagues (PMID 23019153) applied copper-free GHK to keratinocytes and skin, not hair follicles, and found increased p63-positive and PCNA-positive basal keratinocytes, more cuboidal basal-cell morphology, and increased integrin alpha6/beta1 expression, interpreted by the authors as increased "stemness" of epidermal basal cells
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