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Advise patients and caregivers: • how to treat with the overdose reversal agent in the event of an opioid overdose • to tell family and friends about the opioid overdose reversal agent, and to keep it in a place where family and friends can access it in an emergency • to read the Patient Information (or other educational material) that will come with their opioid overdose reversal agent

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reported that MTX caused weight loss due to malabsorption and enterocolitis in rats (Reference Fox, Kripke and De Paula37,Reference Jahovic, Cevik and Sehirli38)