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reliable systemic delivery Intravenous injection – Used in pharmacokinetic characterization and cardiac function studies Subcutaneous injection – Employed in chronic administration protocols for aging research Intramuscular injection – Applied in some exercise performance studies Intranasal delivery – Investigated for CNS-targeted applications when combined with penetrating peptides Common Model Organisms MOTS-c has been studied across multiple species and experimental systems: Mice – Primary research model (C57BL/6, BALB/c strains)