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HCG and Fetal Leydig Cell Development Research Research has confirmed that hCG plays a larger role than fetal pituitary LH in testosterone production by Leydig cells during early fetal development, with the LHCGR not detected in fetal Leydig cells until 10–12 weeks after conception

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HCG protocols, by contrast, carry risks that intensify with duration: electrolyte imbalance, thyroid suppression, and severe rebound weight gain upon discontinuation