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Research suggests the largest improvements often occur in individuals who: Have obesity Have hypertension before starting treatment Lose a substantial amount of weight Have insulin resistance Have metabolic syndrome Improve their nutrition and exercise habits People with higher baseline blood pressure readings generally experience greater reductions than those whose blood pressure is already within a healthy range

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Furthermore, we know that the longer anemia goes untreated, the more neuropsychiatric problems and severity will arise (in an uncertain time frame, shorter or longer)