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In assessing the pathogenic role of ROS in UC, Millar et al (98) examined the influence of exogenous iron (ferric citrate) and iron chelators (desferrioxamine and 1,10-phenanthroline) on the colonic biopsies of patients with UC and normal control subjects

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The perturbation in systemic iron homeostasis was attributed to higher systemic absorption of iron due to enhanced efflux from enterocytes through the basolateral transporter, ferroportin 1