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Not only that, synthetic protein nanoparticles (SPNPs) coated with the transcellular peptide iRGD (AMD3100-SPNPs) can reduce CXCR4+ M-MDSCs infiltration into TME by blocking C-X-C motif chemokine ligand-12 (CXCL12)/CXCR4 signaling, and combined radiation therapy can lead to long-term survival in mouse (132)
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