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Metabolic inhibition of glutamate-cysteine ligase increases dendritic cell-mediated antitumor immunity in melanoma | Journal for ImmunoTherapy of Cancer

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They mitigate the oxidative damage to membrane phospholipids, such as phosphatidylcholine (PC) and sphingomyelin (SM), and restore ceramide (CER) synthesis, which promotes apoptotic pathways in melanoma cells without harming healthy melanocytes 162