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It acts via increasing tight junction protein ZO-1 expression, and transepithelial resistance, inhibiting the mRNA of inflammatory mediators ( iNOS, IL-6, IFNγ , and TNF-α ), and increasing the expression of HSP 70 and 90, and antioxidant proteins, such as HO-1,NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi[6]

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